What children know about the source of their knowledge without reporting it as the source

We argue that, amongst 3- to 5- year-olds, failure to report the source of knowledge recently acquired in answer to “How do you know…?” is due to a specific failure to make a causal inference, in line with source monitoring theory but not fuzzy trace theory. In three Experiments, children (N = 37; 30; 59) identified a hidden toy by seeing, feeling, or by being told, having had two modes of access on each trial, one informative (e.g. seeing a toy identified by colour) and the other uninformative (e.g. being told the toy’s colour by the Experimenter who had only felt it). Children who answered the know question wrongly nevertheless reported accurately who saw and who felt the toy, and what the well-informed player had said. They also realised when the Experimenter’s uninformative access implied their own knowledge was unreliable, suggesting precocious working understanding of knowledge sources

Religiosity and Ways of Coping With Sport Injuries Among Christian Athletes

Although research evidence supports religiosity’s predominantly positive mental and physical health benefits to patients coping with varied health problems, there are few studies exploring the influence of religiosity on coping with sport injuries among athletes identifying with specific religions. This study examined the relationships between religiosity and the use of religious and non-religious ways of coping with sport injuries by athletes affiliated with diverse Christian denominations. Within a concurrent mixed methods design, adult athletes (N = 88) responded to an online survey asking about several religiosity factors, their most serious or challenging sport injuries, and their ways of coping with those injuries. Quantitative results showed that religious commitment correlated with specific religious beliefs and behaviors, positive religious ways of coping predominated over negative, and religious commitment fully mediated the relationship between athletes’ Christian denominations and their use of positive, but not negative, religious ways of coping with sport injuries. Thematic template analysis of qualitative data similarly revealed that religious ways of coping with sport injuries were predominantly positive in valence and benefitted physical and mental rehabilitation and recovery processes. Christian athletes relied on both religious and non-religious coping sources during their sport injury recoveries, and their ways of coping centered on their personal and religious identities. These results support that holistic care models encompassing sport psychology, sports medicine, and sports ministry should adapt intervention and treatment plans to accommodate personal religiosity and build on positive and adaptive religious ways of coping with sport injuries when working with religiously committed Christian athletes

Characteristics of TCR repertoire associated with successful immune checkpoint therapy responses

Immunotherapies have revolutionized cancer treatment. In particular, immune checkpoint therapy (ICT) leads to durable responses in some patients with some cancers. However, the majority of treated patients do not respond. Understanding immune mechanisms that underlie responsiveness to ICT will help identify predictive biomarkers of response and develop treatments to convert non-responding patients to responding ones. ICT primarily acts at the level of adaptive immunity. The specificity of adaptive immune cells, such as T and B cells, is determined by antigen-specific receptors. T cell repertoires can be comprehensively profiled by high-throughput sequencing at the bulk and single-cell level. T cell receptor (TCR) sequencing allows for sensitive tracking of dynamic changes in antigen-specific T cells at the clonal level, giving unprecedented insight into the mechanisms by which ICT alters T cell responses. Here, we review how the repertoire influences response to ICT and conversely how ICT affects repertoire diversity. We will also explore how changes to the repertoire in different anatomical locations can better correlate and perhaps predict treatment outcome. We discuss the advantages and limitations of current metrics used to characterize and represent TCR repertoire diversity. Discovery of predictive biomarkers could lie in novel analysis approaches, such as network analysis of amino acids similarities between TCR sequences. Single-cell sequencing is a breakthrough technology that can link phenotype with specificity, identifying T cell clones that are crucial for successful ICT. The field of immuno-sequencing is rapidly developing and cross-disciplinary efforts are required to maximize the analysis, application, and validation of sequencing data. Unravelling the dynamic behavior of the TCR repertoire during ICT will be highly valuable for tracking and understanding anti-tumor immunity, biomarker discovery, and ultimately for the development of novel strategies to improve patient outcomes

The influence of smoking status on exhaled breath profiles in asthma and COPD patients

Breath analysis using eNose technology can be used to discriminate between asthma and COPD patients, but it remains unclear whether results are influenced by smoking status. We aim to study whether eNose can discriminate between ever- vs. never-smokers and smoking <24 vs. >24 h before the exhaled breath, and if smoking can be considered a confounder that influences eNose results. We performed a cross-sectional analysis in adults with asthma or chronic obstructive pulmonary disease (COPD), and healthy controls. Ever-smokers were defined as patients with current or past smoking habits. eNose measurements were performed by using the SpiroNose. The principal component (PC) described the eNose signals, and linear discriminant analysis determined if PCs classified ever-smokers vs. never-smokers and smoking <24 vs. >24 h. The area under the receiver-operator characteristic curve (AUC) assessed the accuracy of the models. We selected 593 ever-smokers (167 smoked <24 h before measurement) and 303 never-smokers and measured the exhaled breath profiles of discriminated ever- and never-smokers (AUC: 0.74; 95% CI: 0.66-0.81), and no cigarette consumption <24h (AUC 0.54, 95% CI: 0.43-0.65). In healthy controls, the eNose did not discriminate between ever or never-smokers (AUC 0.54; 95% CI: 0.49-0.60) and recent cigarette consumption (AUC 0.60; 95% CI: 0.50-0.69). The eNose could distinguish between ever and neversmokers in asthma and COPD patients, but not recent smokers. Recent smoking is not a confounding factor of eNose breath profiles

Results on Multiple Coulomb Scattering from 12 and 20 GeV electrons on Carbon targets

Multiple scattering effects of 12 and 20 GeV electrons on 8 and 20 mm thickness carbon targets have been studied with high-resolution silicon microstrip detectors of the UA9 apparatus at the H8 line at CERN. Comparison of the scattering angle between data and GEANT4 simulation shows excellent agreement in the core of the distributions leaving some residual disagreement in the tails.Comment: 14 pages, 16 figures. Updated to match published versio

Exhaled metabolite patterns to identify recent asthma exacerbations

Asthma is a chronic respiratory disease that can lead to exacerbations, defined as acute episodes of worsening respiratory symptoms and lung function. Predicting the occurrence of these exacerbations is an important goal in asthma management. The measurement of exhaled breath by electronic nose (eNose) may allow for the monitoring of clinically unstable asthma and exacerbations. However, data on its ability to perform this is lacking. We aimed to evaluate whether eNose could identify patients that recently had asthma exacerbations. We performed a cross-sectional study, measuring exhaled breath using the SpiroNose in adults with a physician-reported diagnosis of asthma. Patients were randomly divided into a training (n = 252) and validation (n = 109) set. For the analysis of eNose signals, principal component (PC) and linear discriminant analysis (LDA) were performed. LDA, based on PC1-4, reliably discriminated between patients who had a recent exacerbation from those who had not (training receiver operating characteristic (ROC)–area under the curve (AUC) = 0.76,95% CI 0.69–0.82), (validation AUC = 0.76, 95% CI 0.64–0.87). Our study showed that, exhaled breath analysis using eNose could accurately identify asthma patients who recently had an exacerbation, and could indicate that asthma exacerbations have a specific exhaled breath pattern detectable by eNose

On the distance and reddening of the starburst galaxy IC10

We present deep and accurate optical photometry of the Local Group starburst galaxy IC10. The photometry is based on two sets of images collected with the Advanced Camera for Surveys and with the Wide Field Planetary Camera 2 on board the Hubble Space Telescope. We provide new estimates of the Red Giant Branch tip (TRGB) magnitude, m_{F814W}^{TRGB}=21.90+-0.03, and of the reddening, E(B-V)=0.78+-0.06, using field stars in the Small Magellanic Cloud (SMC) as a reference. Adopting the SMC and two globulars, Omega Centauri and 47 Tucanae, as references we estimate the distance modulus to IC10: independent calibrations give weighted average distances of mu=24.51+-0.08 (TRGB) and mu=24.56+-0.08 (RR Lyrae). We also provide a new theoretical calibration for the TRGB luminosity, and using these predictions we find a very similar distance to IC10 (mu~24.60+-0.15). These results suggest that IC10 is a likely member of the M31 subgroup.Comment: 4 pages, 4 figures, ApJ Letters accepte

Relative distances of Omega Centauri and 47 Tucanae

We present precise optical and near-infrared ground-based photometry of two Globular Clusters (GCs): Omega Cen and 47 Tuc. These photometric catalogs are unbiased in the Red Giant Branch (RGB) region close to the tip. We provide new estimates of the RGB tip (TRGB) magnitudes--m_I(TRGB)=9.84+/-0.05, Omega Cen; m_I(TRGB)=9.46+/-0.06, 47 Tuc--and use these to determine the relative distances of the two GCs. We find that distance ratios based on different calibrations of the TRGB, the RR Lyrae stars and kinematic distances agree with each other within one sigma. Absolute TRGB and RR Lyrae distance moduli agree within 0.10--0.15 mag, while absolute kinematic distance moduli are 0.2--0.3 mag smaller. Absolute distances to 47 Tuc based on the Zero-Age-Horizontal-Branch and on the white dwarf fitting agree within 0.1 mag, but they are 0.1--0.3 mag smaller than TRGB and RR Lyrae distances.Comment: 5 pages, 4 figures, accepted for publication by ApJ